Rhona casts as Laura Tollins in the movie "The Number 23" in 2007 directed by Joel Schumacher starring Jim Carrey, Virginia Madsen, Logan Lerman, Lynn Collins and many other famous actors.
She also acted in "Shooter" in 2007 enacting the role of Alourdes Galindo.
The movie "Shooter" [2007] is directed by Antoine Fuqua casting Mark Wahlberg, Michael Pena, Danny Glover and Kate Mara.
Mitra acted the role of Maj. Eden Sinclair in the movie "Doomsday" in 2008 directed by Neil Marshall.
She performed the role of Sonja in the Patrick Tatopoulos directed film, "Underworld: Rise of the Lycans" [2009]. The movie casts Michael Sheen and Bill Nighy.
Rhona Mitra went on acting in other films like "Stolen Lives" [2009], "Separation City" [2009] and "Re-Uniting the Rubins" [2009].
She hosted the music series British Channel 5's "The Pepsi Chart Show" for two years.
She is good friends with musician John Mayer.
Rhona Mitra auditioned and received the part of video game character Lara Croft from the "Tomb Raider" action series.